Profile avatar
svmahler.bsky.social
Behavioral Neuroscientist, Prof, ICAN co-Director, Ivan Pavlov fan. Interested in rats, drugs, motivation circuits, orexin, VP, DREADDs, psychedelics, neurodevelopment, etc https://faculty.sites.uci.edu/mahlerlab/ http://www.youtube.com/@stephenvmahler56
43 posts 1,233 followers 571 following
Prolific Poster

An 80-year-old model of American science is under threat. www.nytimes.com/interactive/...

Neuroscience research and training has taken a $323 million hit in the form of grants rescinded by the U.S. NIH, according to an analysis by @thetransmitter.bsky.social. By @claudia-lopez.bsky.social #neuroskyence www.thetransmitter.org/funding/nih-...

The judge’s order will restore funding only to the scientists named in the lawsuits and in the 16 states that sued the government — or about 800 of the more than 2,400 projects that have been cut at the NIH.

There will be a huge loss to the training of new researchers, loss of opportunities to create new knowledge, loss of innovation and all of this will be very hard to measure.

How bad will it be? Catastrophic. Proposed cuts to #NSF, #NIH, and #NASA will set the US R&D landscape back 25 yrs+, cause economic and job loss now, and undermine innovations to come. But, this is the WH's *proposed* budget. Speak up now before it is too late. (inflation adjusted $-s below)

Remember folks, the budget cuts for NSF and NIH *can still be stopped*. That is a luxury not granted to our agency science colleagues who have or could still lose their jobs from the top down. So - Fight! Speak up! Pay attention!

Damn... I wonder why scientists wouldn't want to come to the US to compete at the highest levels for highly-restricted funding that then gets pulled surreptitiously for some imagined reason or no reason at all, all while being vilified by the federal government for their work? A mystery! 🤔

Not that it matters, but my MOSAIC was scored a 14. Reviewed in study section w non-MOSAIC K99s. I'm to write another grant that may not be funded, that doesn't provide transition to faculty funds, instead of doing the work that was reviewed so highly? That's the best use of time & tax payer money?

New interview w NIH Dir Bhattacharya. "I think that the idea that the US no longer supports science or scientists is laughable." "Many, many people now think that mRNA is a bad platform." Dismisses research on structural racism & health as "not a scientific idea" www.politico.com/news/magazin...

Excellent review by @talliezee.bsky.social and Matthew T. Birnie on the neurobiological mechanisms underlying the consequences of early life adversity. Highly recommended! www.cell.com/neuron/fullt...

I appreciate the offers from other scientists to help Harvard (students, labs, etc) through this attack, but what would be most helpful is for you to use your position to contact your elected representatives and make it clear this fight isn't just Harvard, it will affect you, and their districts too

“This will destroy the university as we know it. Harvard is situated in the US physically, but its students & faculty hail from around the world; that is fundamental to the work & mission of the institution. You can't take that away & have an institution left." — Kirsten Weld, President Harvard AAUP

Given that we expect layoffs from the planned reduction in NASA's science budget, JPL doing this is akin to forcing people out now without paying severance. The knowledge and expertise that will end up leaving JPL will set back research and projects decades. /1

Please comment. The Administration is trying to turn the NIH IC Directors and program staff roles into political appointees that serve at the whim of the President. Imagine if each change in administration brought sweeping changes in professional NIH staff across your favorite ICs.

It is beyond disturbing when the NIH and HHS Directors do not understand that animal models are essential in research www.statnews.com/2025/05/19/a...

This from @stuartbuck.bsky.social ought to be obvious, but is no longer so in the age DOGE. open.substack.com/pub/goodscie...

Having a hard time processing this. HHMI is pausing all competitions. Very demoralizing for early career scientists like me @hhmi.org

Dozens of responses to my essay summarized. 1. Why aren’t scientists in an uproar? 2. Most Americans don't know that defunding science will make their lives worse. Bluesky, tell your neighbors, science matters. Scientists, roar. 🧪💙📚 #scicomm #science 🌎 🔬 ⚒️ theconversation.com/unprecedente...

NSF just cancelled ALL grants to Harvard researchers. That’s right - physics, astronomy, bio, CAREER - ALL. Professors won’t get paid. Postdocs won’t get paid. PhD students won’t get paid. This is insane! If they can do this to Harvard, they can do this to your school.

Thrilled to announce that our paper is now finally out! 🎉We combine scRNAseq, 2p imaging, ephys, and behavior to understand the role of lateral septal Nts neurons in opioid withdrawal. Curious about the septum and addiction? Give it a read👇 www.cell.com/neuron/fullt...

Demand for heroin in rats: effects of non-drug alternative substitutes and complements 👉 Opioid value depends on the broader behavioral economic context in which opioids and non-drug alternatives are available www.nature.com/articles/s41...

Current situation at Harvard Medical School for NIH grants view.u.hms.harvard.edu?qs=3ed8c01b9...

NIDA shutters diversity fellowship program, axes active awards www.thetransmitter.org/funding/nida... Thank you @callimcflurry.bsky.social for writing on this topic

The US has cut the equivalent of 3X the total annual CIHR budget so far this year, revealing both how low the CIHR budget is and how utterly draconian the White House has treated one of the most precious and successful institutions the US has ever built.

The videocast of the open portion of the NIDA Advisory Council meeting will start in 25 min. Should be a fascinating read on the state of NIDA. videocast.nih.gov/livew.asp?li...

Meanwhile I can’t accept any “gift” from a vendor valued at over $5. But hey, I get paid $400 to review grants for the NIH, which takes ~40-60 hours.

I know NIH is ~5x bigger than NSF but I think the gutting of NSF is getting a lot less than 1/5 the attention— in the news media and in higher ed— compared with what's happened to NIH.

HAPPY 75th, NSF! We’re celebrating this milestone by highlighting some of NSF’s most transformative accomplishments—innovations that have shaped our world and continue to drive progress in health, technology, the environment, and beyond. Read on 🧵(1/11):

I think we need to remember that there are two goals for this administration: delaying or stopping funding outright AND chilling the enthusiasm for participating in the biomedical research enterprise. Research is most successful, and inclusive, when its support is stable and certain.

No-cost extensions of NIH grants are no longer automatically approved drugmonkey.wordpress.com/2025/05/09/n...

"Let’s be clear: It isn’t institutions that are being punished. It’s the researchers who are the future of science in this country — the ones who spend long hours at lab benches, running experiments, analyzing data." #SpeakOut #BrainDrain www.statnews.com/2025/05/07/u...

Several Members of ACNP are in Washington D.C. today to meet with elected officials. This photo includes ACNP Executive Director Sarah Timm, Dr. Hilary Marusak, and Dr. Sara Nixon. #ABCHillDay - acnp.org

If you want your kids and grandkids to go to school, if you want there to be treatments for dementia and cancer, if you want to live in a society where people learn freely and think critically, this should be ALARMING to you.

Together with leading science organizations, ASM filed an amicus brief calling for immediate restoration of NIH grants supporting early-career scientists. Read the press release: asm.org/press-releas...

J. Wellington Wimpy first appeared in the Thimble Theatre newspaper strip dated May 3, 1931.

I must once again repeat: CONTACT 👏🏽 YOUR 👏🏽 OFFICE 👏🏽 OF 👏🏽 SPONSORED 👏🏽 PROJECTS 👏🏽 TO 👏🏽 FIND 👏🏽 OUT 👏🏽 HOW 👏🏽 TO 👏🏽 INITIATE 👏🏽 AN 👏🏽APPEAL 👏🏽

Grant cancellations of any kind are terrible and disruptive, but I've been thinking a lot about the compounding effects that cancelling trainee grants will have - so many promising young people left discouraged and (rightfully) contemplating careers outside of science.

The disconnect here is astonishing.

👀

New review from Kasey Brida on transcriptional & molecular mechanisms in drug-induced plasticity. Here we focused on mechanisms that determine which neurons are activated by drugs, and dynamic transcriptional cascades that facilitate plasticity in these cells. www.sciencedirect.com/science/arti...

All NIDA F31 diversity scholars officially losing their funding... I barely have words. Expected at this point but so so disappointing and unfair. We are effectively punishing some of America's best science students for telling the government they are from an underrepresented community.

This is such a powerful way to put this! Thank you!

As part of their plan to GUT the science mission at NASA, Trump and Musk want to cancel the Nancy Grace Roman Space Telescope — a critical project that is on time, under budget, and nearly finished. They want to flush those taxpayer dollars down the drain. How is THAT efficient?

“This notion that universities will be able to hide in the shadows while others are being attacked is an extremely dangerous and cowardly approach." It's high time universities stand up and fight back. #defendhighered

As predicted, we are now seeing the US science brain drain. We will be losing incredible talent, scientific discovery, patents, novel therapeutics, and health & disease treatment and prevention. This pool of experts will take their research and trainees, current and future talent, with them 👇👇👇👇

What happens to the rest of the🧠when we silence our favorite node / projection? 🧪innovative #fMRI & computation modeling uncover curious, location-dependent connectivity remaps. Bravo! www.pnas.org/doi/10.1073/... @univ-amu.fr @svmahler.bsky.social @ahmarilab.bsky.social @aaronbornstein.bsky.social