xiongliu.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

Mark Huising from University of California, Davis, presents research on how dynamic crosstalk within the islet shapes insulin release. 🗣️ Don’t miss today's debate “Are alpha cells and glucagon needed for islet function and glucose homoeostasis?”, chaired by Mark @huisinglab.bsky.social #EISG2025.

submitted 4 days ago • 0 comments

Our home-brewed PI3P and PI4P probes in neurons feels like blowing bubbles as a kid: fleeting, a little magical. I’m a Doubting Thomas at ❤️ & why I spend so much time learning to image & build probes. I need to see it to believe it. Too late for #fluorescencefriday but in time for #microscopymonday

submitted 7 days ago • 2 comments

🤣🤣🤣🤣🤣

submitted 9 days ago • 0 comments

edmonton.citynews.ca/2025/06/05/u...

submitted 11 days ago • 0 comments

Exciting news, although I guess the logic here seems to be that if you can buy genius, why train your own🤔.

submitted 11 days ago • 0 comments

Like this sentence:" If I received this review, would I view it as fair?"😀

submitted 14 days ago • 0 comments

Important changes on @erc.europa.eu grants‼️Grant structure & most importantly eligibility timeframes (10 years for starting, 15 years for consolidator post PhD-but you can have them only once) changes: erc.europa.eu/news-events/...

submitted 15 days ago • 0 comments

Well, I'm gonna hold my nose, cover my eyes and published this. A longer form story in two parts, first up glucagon antagonist drugs and briefly why they failed today. And then next week, glucagon agonists and why they look to succeed. Hope y'all like it!

submitted 17 days ago • 3 comments

Got the job without having any CNS papers

submitted 38 days ago • 6 comments

New study on novel translation factor EIF2A led by Panzhinskiy as a collaboration between @jimjohnsonsci.bsky.social lab, Jan lab & @bruceverchere.bsky.social lab UBC Life Sciences Institute. Thanks Breakthrough T1D Canada for funding this project #DiabetesResearch link.springer.com/article/10.1...

submitted 39 days ago • 0 comments

Interrogation of Proglucagon-derived peptide secretion using human stem cell-derived alpha (SC-α) cells www.cell.com/stem-cell-re...

submitted 39 days ago • 0 comments

This is one of the best ads I have ever seen and I can’t believe I missed it

submitted 44 days ago • 180 comments

EIF2A is a novel target for beta cell protection and the circumvention of EIF2S1-mediated translational repression #islets #diabetes @jimjohnsonsci.bsky.social @diabetologiajnl.bsky.social link.springer.com/article/10.1...

submitted 47 days ago • 0 comments

Check out this pre-print from Vira Kravets, Andraz Stozer and myself, for the influence of alpha cells on heterogenous islet Ca2+ responses, including first-responders and first phase timing/amplitude. Was great to be part of this! www.biorxiv.org/content/10.1...

submitted 48 days ago • 0 comments

Thrilled to share our latest work, which was the outstanding doctoral work of @samanthajsyoon.bsky.social academic.oup.com/endo/advance... 1/12

submitted 48 days ago • 1 comment

Molecular Correlates of Glycine Receptor Activity in Human β Cells https://www.sciencedirect.com/science/article/pii/S2212877825000638

submitted 58 days ago • 0 comments

“Recruiting U.S. scientists is a fine idea – except we’re barely supporting Canadian scientists as it is” https://www.theglobeandmail.com/gift/aaa9fec50b2b595cc0291494fc97e4bd10e7d6945d5c457e0bfa75d42846a705/4FRDBEKLNFESVJ3ZILAS36KR7Y

submitted 59 days ago • 7 comments

When failed at the fellowship, I got this... Never stop, keep trying!!!

submitted 60 days ago • 0 comments

The Lim Lab at the @crchum.bsky.social is recruiting PhD students or Postdoctoral Fellows to study the roles of 14-3-3zeta in #adipocytes or pancreatic #betacells. Projects are supported by CIHR, NSERC, or Diabetes Canada. Please share with people who might be interested! Thanks!

submitted 64 days ago • 0 comments

#hiring. Opportunité de financement pour un MSc ou PHD @ualberta.bsky.social pour les talents #marocains 🇲🇦. Nous recherchons un(e) candidat(e) motivé(e) pour étudier les mécanismes de régulation de la sécrétion d’insuline et leurs implications dans le diabète. shorturl.at/KCPNQ

submitted 66 days ago • 0 comments

If you want to understand how cells function, you have to work out what proteins interact with — and where https://go.nature.com/3RgNXOZ

submitted 65 days ago • 1 comment

Uh......... Unmarried individuals may have a lower risk of dementia compared to married adults. alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

submitted 66 days ago • 0 comments

I said what I said about our provincial research funding environment. We have the lowest per capita provincial research investment in Canada and that is a lost opportunity and as someone who is proud to be doing research in Manitoba I want better www.winnipegfreepress.com/breakingnews...

submitted 69 days ago • 1 comment

Dou et al. used optogenetics in conjunction with electrophysiology, [Ca2+]i imaging and hormone release measurements to explore the intrinsic and paracrine regulation of glucagon secretion. 🧪 #PancSky diabetesjournals.org/diabetes/art...

submitted 71 days ago • 0 comments

Down to earth (as always) interview with @danieljdrucker.bsky.social on the impact of GLP1 agonists in fields of biology that he’d never anticipated but is leading the way on understanding - as awardee of th3 Breakthrough Prize with colleagues. www.ctvnews.ca/sci-tech/art...

submitted 72 days ago • 3 comments

Timescales in Cell Biology

submitted 74 days ago • 0 comments

1 day left to apply!

submitted 74 days ago • 0 comments

www.nature.com/articles/s41...

submitted 74 days ago • 0 comments

RNA-seq analysis and experimental exploration show that TMEM55A-mediated PI5P signalling regulates #alphacell actin depolymerisation and #glucagon secretion. #islets, #diabetes link.springer.com/article/10.1... 🔓 @xiongliu.bsky.social @bcellorg.bsky.social

submitted 74 days ago • 0 comments

Found an interesting paper in 1955😅 www.nature.com/articles/175...

submitted 76 days ago • 0 comments

uh....

submitted 77 days ago • 0 comments

The expression order determines the pioneer functions of NGN3 and NEUROD1 in pancreatic endocrine differentiation | Science Advances www.science.org/doi/10.1126/...

submitted 81 days ago • 0 comments

Kind of switching to #CellProfiler (Seems to make life easier compared with #Fiji/#ImageJ)

submitted 81 days ago • 0 comments

🚨Publication from @bcellorg.bsky.social Excited to see my first postdoc story published in @diabetologiajnl.bsky.social. We started with statistical analysis from www.humanislets.com to get an idea (left). We found a novel alpha cell glucagon regulation mechanism by TMEM55A(right). Link is below.

submitted 82 days ago • 1 comment

A novel pathway by which TMEM55A regulates alpha cell exocytosis by controlling intracellular PI5P and the F-actin network. @bcellorg.bsky.social @diabetologiajnl.bsky.social #islets link.springer.com/article/10.1...

submitted 82 days ago • 0 comments

www.embopress.org/doi/full/10....

submitted 82 days ago • 0 comments

🔬 Th1nk Tank Alert! 🔬 How does mitochondrial signaling shape metabolic tissue identity? 🧬 🗓 Apr 17, 2025 | 12 PM ET 🔗 Register: us02web.zoom.us/meeting/regi... #DiabetesResearch #T1D #Mitochondria #BetaCells #IsletBiology #CellMetabolism #BiomedicalScience

submitted 88 days ago • 0 comments

🔬 How do molecular pathways drive islet dysfunction in T1D? 🔬Join to explores islet cell dysfunction in human T1D. 📝 Register: us02web.zoom.us/meeting/regi... #DiabetesResearch #T1D #IsletBiology #MolecularPathways #BetaCells #Bioinformatics #Autoimmunity #Endocrinology

submitted 88 days ago • 0 comments

www.nature.com/articles/s42...

submitted 88 days ago • 0 comments

More mouse data highlight key roles of vasopressin as a mediator of glucagon release in response to dehydration, hyperosmolarity and dapigliflozin journals.physiology.org/doi/abs/10.1...

submitted 90 days ago • 0 comments

A new output from our lab in Montreal around the role of ER calcium stores in ensuring beta cells remain connected: #LuisDelgadillo #KarenDakessian www.biorxiv.org/content/10.1...

submitted 92 days ago • 0 comments