1/Happy new year from the Metastasis Research Society! As we close out 2024, here are some additional studies that have shaped our understanding of metastasis biology this year. 🧵... - ThreadSky

metastasisresearch.bsky.social • 79 days ago

1/Happy new year from the Metastasis Research Society!

As we close out 2024, here are some additional studies that have shaped our understanding of metastasis biology this year. 🧵...

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metastasisresearch.bsky.social•79 days ago

2/ The relative scarcity of interactions between dormant disseminated tumor cells (DTC) and antigen specific T-cells explains immune evasion for metastasis! The authors reveal immune-strategies to overcome this for DTC eradication.

Cyrus Ghajar @fredhutch.bsky.social

https://www.cell.com/cancer-cell/abstract/S1535-6108(23)00439-7

metastasisresearch.bsky.social•79 days ago

3/Chronic stress drives metastasis! Here the authors reveal that exposure to chronic stress results in neutrophil-mediated remodeling of the tumor microenvironment through glucocorticoids for metastasis!

Xueyan He @megeblad.bsky.social

https://www.cell.com/cancer-cell/abstract/S1535-6108(24)00037-0

metastasisresearch.bsky.social•79 days ago

4/Astrocyte-mediated upregulation of CDK5 in breast cancer brain metastases drives immune evasion! The authors find that the CDK5 inhibitor roscovitine antagonizes this pathway for immune-eradication of brain mets!

Dihua Yu @mdanderson.bsky.social

https://www.nature.com/articles/s41556-024-01509-5

metastasisresearch.bsky.social•79 days ago

5/Sex and age in metastasis. In this study, the authors find that aged, male fibroblasts intrinsically downregulate EZH2 resulting in elevated BMP2 secretion which drives a highly invasive and therapy-resistant melanoma.

Yash Chhabra @ashi-w.bsky.social

https://www.cell.com/cell/abstract/S0092-8674(24)00904-8

metastasisresearch.bsky.social•79 days ago

6/Timing of pancreas cancer metastasis. By profiling patient samples, the authors reveal immune remodeling in the pre-metastatic liver and propose liver sampling to determine pancreas cancer metastatic propensity.

David Lyden Weill Cornell

https://www.nature.com/articles/s41591-024-03075-7

metastasisresearch.bsky.social•79 days ago

7/Epigenetic states define disseminated tumor cell (DTC) fate. In this study, the authors find that hypomethylated DTCs respond to WNT ligands, extravasate and undergo dormancy, while methylated DTCs proliferate intravascularly.

@hellmutaugustin.bsky.social

https://www.nature.com/articles/s43018-023-00716-7

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