Strikingly, as predicted by the theory: 🔹DCs (consumers) and T cells (sensors) migrated as coupled travelling waves 🌊 🔹T cells stayed at a conserved distance ahead of DCs! - ThreadSky

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mehmetcanucar.bsky.social • 143 days ago

Strikingly, as predicted by the theory:

🔹DCs (consumers) and T cells (sensors) migrated as coupled travelling waves 🌊
🔹T cells stayed at a conserved distance ahead of DCs!

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mehmetcanucar.bsky.social•143 days ago

Moreover, the spatial profiles of the cell populations matched the theoretical predictions:

T cells (sensors) showed a concentration peak ahead of DCs (consumers), despite being unable to migrate alone -purely driven by DC-generated gradients!

mehmetcanucar.bsky.social•143 days ago

Importantly, after fitting our model with experimental data, we found that DC-T cell migration sits close to the optimal regime (🌟), where both co-migration and colocalization are maximized:

mehmetcanucar.bsky.social•143 days ago

Finally, we explored whether mechanical interactions between different cell types could also drive efficient co-migration, like in nonreciprocal interactions where population A attracts B, while B repels A 💔

mehmetcanucar.bsky.social•143 days ago

Turns out, mechanical nonreciprocity only affects migration dynamics when consumer cells are weakly chemotactic: For sufficiently chemotactic consumers, biochemical non-reciprocity dominates over mechanical forces!

mehmetcanucar.bsky.social•143 days ago

Overall, we find that self-generated chemotaxis provides an elegant strategy for robust migration of heterogeneous cell populations -which could be important for understanding immune function & beyond!

mehmetcanucar.bsky.social•143 days ago

This was a really cool work with @ehannezo.bsky.social & Michael Sixt, with Zane Alsberga leading experiments and building on our recent work with Jonna Alanko!

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