mTOR inhibitors have some independent nephrotoxicity though mostly proteinuria?
But I did not know they are thought to be synergistic with CNI toxicity
https://pmc.ncbi.nlm.nih.gov/articles/PMC7080294/ @ssfarouk.bsky.social mentions risk of TMA is higher but not chronic toxicity
But I did not know they are thought to be synergistic with CNI toxicity
https://pmc.ncbi.nlm.nih.gov/articles/PMC7080294/ @ssfarouk.bsky.social mentions risk of TMA is higher but not chronic toxicity
Comments
"[Sirolimus] approval came from the EMEA with clear guidance to withdraw cyclosporine at an early time point, due to what was then recognized as the synergistic nephrotoxicity of using SRL with full-dose CNI"
From responses, it seems there is no prospective RCT data supporting a switch from mTOR/CNI to MMF/CNI in improving long term kidney function but perhaps it might help based on animal model and retrospective data? Is this the right take?
https://pmc.ncbi.nlm.nih.gov/articles/PMC6572069/