#Spatialtranscriptomics is revolutionizing gene expression profiling at subcellular resolution! 🔬These 'molecular microscopes' can unlock disease mechanisms & guide therapies...but how to bring ST to the clinic? Our thoughts w @N_Rajewsky & @nukappa.bsky.social out @annualreviews.bsky.social 🧵👇 - ThreadSky

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tmpentimalli.bsky.social • 38 days ago

#Spatialtranscriptomics is revolutionizing gene expression profiling at subcellular resolution!

🔬These 'molecular microscopes' can unlock disease mechanisms & guide therapies...but how to bring ST to the clinic?

Our thoughts w @N_Rajewsky & @nukappa.bsky.social out @annualreviews.bsky.social

🧵👇

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tmpentimalli.bsky.social•38 days ago

Check our review on the 'Challenges & Opportunities in Clinical Translation of High-Resolution Spatial Transcriptomics (ST)'!!
https://annualreviews.org/content/jour...

tmpentimalli.bsky.social•38 days ago

1/ High-resolution ST omics work as molecular microscopes, digitalizing gene expression and tissue morphology at subcellular resolution. This enables the interactive exploration of millions of transcripts and their comparison with routine histology and pathologist annotations.

tmpentimalli.bsky.social•38 days ago

2/ With high-resolution ST we can study tissue organization in 2D and 3D virtual tissue blocks, analyzing the organization of cells in multicellular niches and identifying which receptor–ligand interactions orchestrate their function in situ.

tmpentimalli.bsky.social•38 days ago

3/ In the clinic, spatial biomarkers and patient-specific molecular mechanisms identified by ST hold great potential to inform patient care and help the discovery of novel drug targets, as showcased in early preclinical studies

tmpentimalli.bsky.social•38 days ago

4/ Several challenges exist to their swift clincal translation: What is the ‘best’ ST method? How do we turn complex molecular data into meaningful insights for patient care? How do we integrate in clinical routines?

tmpentimalli.bsky.social•38 days ago

5/ As large-scale clinical studies are urgently needed to link spatial biomarkers with patient outcomes, we discuss key considerations for the design of clinical ST projects from sample preservation and method choice to panel design and power analysis.

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