So how do BMP (and Agouti) drive fate conversion? Transcription factors Foxd3 (well known) and Runx3 (not well known in pigment biology) are downstream of BMP and necessary and sufficient to effect melanin loss and purine gain.
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We believe this is all pretty cool because (i) it shows how a differentiated cell type has been “repurposed” to have an entirely new phenotype and (ii) it shows the importance of positional information even in a species best known for self-organizing its pattern.
As usual, a heroic job from our own folks, especially Dylan, and great fun working with our collaborators, and of course thanks to NIH and the MIRA mechanism for letting us go where the science leads.
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