@mzhlab.bsky.social I am proud to share our manuscript published in @ANA_journals today. http://doi.org/10.1002/ana.27157
We used data-driven approaches to analyze paired #CSF and blood #FlowCytometry of 8,790 (discovery) + 3,201 (validation) patients
A #tweetorial 1/16
We used data-driven approaches to analyze paired #CSF and blood #FlowCytometry of 8,790 (discovery) + 3,201 (validation) patients
A #tweetorial 1/16
Comments
In most CSF laboratories, leukocytes are only grossly classified as lymphocytes, monocytes, and granulocytes. In our center, flow cytometry is routinely performed in CSF and blood.
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In a subcohort of 788 somatoform patients, we found that #Tcells in blood were increased in females, while albumin, protein, IgG, IgA, and IgM ratios were increased in males.
Age primarily affected #Tcells in #CSF and blood, which became activated with age. Interestingly, #CD8Tcells increased in #CSF with age but decreased in blood, suggesting that age-related changes are partially compartment-specific.
We next trained an #XGBoost model on 588 somatoform patients and found that the prediction on the remaining 200 patients showed a strong correlation with true biological age (Pearson r = 0.71).
We next speculated that #CSF or blood analysis could allow us to classify neurological diseases in an unbiased, data-driven approach—inverse to routine #ClinicalNeurology.