Heterozygous mutations in leptin receptor gene (LEPR) do not cause obesity. The finding goes against the rationale for a recent clinical trial that test setmelanotide for obesity treatment in heterozygous carriers of LEPR variants.

Delplanque et al. AJHG
https://www.sciencedirect.com/science/article/abs/pii/S0002929724003835?via%3Dihub