Out now: the study on human inflammatory cardiomyopathies after SARS-CoV-2 infection and COVID-19 vaccination led by researchers from @mdc-berlin.bsky.social/@dzhk.de/Charité Berlin with tiny contribution from us @mdc-bimsb.bsky.social – short summary below. … (1/5)

https://www.nature.com/articles/s44161-025-00612-6

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As many other pathogens, also infections with SARS-CoV-2 can lead to myocarditis. This condition was also observed in some cases following mRNA-based vaccinations. Here, we profiled 8 non-Covid, 10 Covid, 4 vaccination and 18 control cases using single-nucleus sequencing of heart biopsies. … (2/5)
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Where as some features were common between the groups (myeloid cell expansion, loss of resident macrophages), infection was characterized by CD8+ T cell influx, where as vaccinee cases rather had CD4+ T cells. … (3/5)
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In the myocarditis post infection condition, Interferon gamma was highest, whereas vaccination-induced myocarditis rather led to high Il-16/Il-18 levels. The latter was also marked by higher levels of the dampening cytokines Tgf beta and Il-34. … (4/5)
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Overall, we identify common and distinct features of myocarditis cases caused by infection or vaccination. In the future, long-term consequences of the disease should be studied. The results can also help optimizing mRNA vaccinationsto reduce the risk for post-vaccination myocarditis. (5/5)
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