Proud to share our @nature.com paper, co-led by Chadi El Farran & Charles Couturier under mentorship of Brad Bernstein where we develop a new framework to understand immunomodulatory myeloid cells in #glioma & lay a foundation to develop more effective immunotherapies. www.nature.com/articles/s41... - ThreadSky

tymillerlab.bsky.social • 4 days ago

Proud to share our @nature.com paper, co-led by Chadi El Farran & Charles Couturier under mentorship of Brad Bernstein where we develop a new framework to understand immunomodulatory myeloid cells in #glioma & lay a foundation to develop more effective immunotherapies. https://www.nature.com/articles/s41586-025-08633-8

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brianliau.bsky.social•4 days ago

Congratulations!!

tymillerlab.bsky.social•4 days ago

Thanks Brian!!

albertoreale.bsky.social•21 hours ago

Since myeloid cells from peripheral blood infiltrate well brain tumors, they are so interesting also as possible carriers for therapeutics!

tymillerlab.bsky.social•4 days ago

Quick tangent: we are recruiting postdocs! This work lays a foundation of discovery & translation that I’ve brought to my own lab @caseccc.bsky.social & CWRU SOM – where we have built a fun, collaborative, & intelligent team driven to make an impact. Join us! https://tymillerlab.org/our-team/

tymillerlab.bsky.social•4 days ago

6 yrs ago, when I started residency @ MGH & joined Brad's lab, I asked a Q: “What’s our best shot at a cure for #glioma patients?”
A: Immunotherapy.
Q: “How do we make immunotherapy effective for glioma?”
A: Start by tackling the immunosuppressive myeloid cells.

tymillerlab.bsky.social•4 days ago

So that’s what we set out to do. While we knew about malignant cells in glioma from scRNA-seq studies & had some consensus in the field, that’s not the case for myeloid cells. So 1st, we set to create consensus myeloid programs across gliomas(which are diverse = need many tumors)

tymillerlab.bsky.social•4 days ago

I could go on for 20 tweets about how we got to these programs (it took 2 years to develop the strategy we felt captured the true consensus programs), but the key was utilizing cNMF (from @dkotliar.bsky.social @pardissabeti.bsky.social)rather than the standard Louvain clustering w/UMAP (see methods)

tymillerlab.bsky.social•4 days ago

There were 14 superimposable programs. 5 cell identity programs (defines cell type of cell), and 9 activity programs (what cell is doing). Notably, 4 of these activity programs seem immunomodulatory in their activity, with 2 inflammatory and 2 suppressive

tymillerlab.bsky.social•4 days ago

Surprisingly, these 4 immunomodulatory were the most utilized programs across myeloid cells (d). Nearly all (91%) of myeloid cells in our gliomas expressed at least one of these 4 programs

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