1/A fascinating figure that reveals so much about both genetics and clinical psychiatry from a great new #bipolar #genetics paper out in @nature.com www.nature.com/articles/s41... - ThreadSky

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abesterman.bsky.social • 32 days ago

1/A fascinating figure that reveals so much about both genetics and clinical psychiatry from a great new #bipolar #genetics paper out in @nature.com
https://www.nature.com/articles/s41586-024-08468-9#MOESM1

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abesterman.bsky.social•32 days ago

2/ Take a close look at the order of diagnostic cohorts (trait 1) along the strength of genetic correlation (rg) between disorders.

For schizophrenia, the disorder with strong evidence linking it to bipolar disorder, a highly reliable diagnosis of BP1 is most strongly genetically corr (high rg)

abesterman.bsky.social•32 days ago

3/ For MDD, PTSD, BPD the order is flipped, that is the least reliable diagnostic methods of diagnosing BP (e.g. self-report, community dx) are most strongly correlated w/ these dx. This suggests that self- or community-diagnosed bipolar may actually be a high % of people with other psych disorders

abesterman.bsky.social•32 days ago

4/ This is consistent with clinical experience; bipolar disorder may be the most mis/over-diagnosed psych disorder. Psychiatrists spend a lot of time 'undiagnosing' it. Both clinical experience and genetics converge on this same message very nicely.

abesterman.bsky.social•32 days ago

5/ We need to do a better job of public education about #bipolardisorder so people understand that it is more than just "normal ups and downs".

@doctorveera.bsky.social @psychunseen.bsky.social @j9austin.bsky.social @markruffalo.bsky.social

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