The peak of HA in the lung coincides with the peak of the #type2immune response - which we know to be essential for effective #repair of the tissue damage caused by the parasite 🪱
Mice that lack #IL-13 have a reduced type-2 response and we found they have less #HA at day 7 post infection... But IL-13 deficient mice have more tissue damage - highlighting an important IL-13-HA-tissue repair pathway that were investigating further 👀
Parasite models have taught us so much about how the immune response is regulated - we think they can also teach us a lot about immune-mediated matrix formation and it's roles in effective (or not!) tissue repair
Super grateful 💚 for support from my supervisors @drtesutherland.bsky.social @profjudiallen.bsky.social and Tony Day. Excited that we can continue to answer questions about immuno-matrix interactions in lung health thanks to support from @wellcometrust.bsky.social watch this space....
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