Not easy to describe the emotions of seeing our work published in @cellpress.bsky.social ! We explored how novel isoforms emerge during evolution through the exonization of Transposable Elements. Exonized TEs modify the functions and structures of host proteins. www.cell.com/cell/fulltex... - ThreadSky

yarribas.bsky.social • 153 days ago

Not easy to describe the emotions of seeing our work published in @cellpress.bsky.social ! We explored how novel isoforms emerge during evolution through the exonization of Transposable Elements. Exonized TEs modify the functions and structures of host proteins.
https://www.cell.com/cell/fulltext/S0092-8674(24)01328-X

Comments

kevinng.bsky.social•152 days ago

Congratulations, amazing paper!

paubadiam.bsky.social•150 days ago

Molt interessant, enhorabona Yago! 🥳

yarribas.bsky.social•150 days ago

Gràcies Pau! Justament citem algun article teu! Fa il·lusió veure com tot està connectat! 😊

olivier-saulnier.bsky.social•148 days ago

Bravo https://yarribas.bsky.social‬, really great work!

jrossibarra.bsky.social•152 days ago

Looks super cool. Already added to our journal club for reading soon!

yarribas.bsky.social•152 days ago

Thank you! I hope it leads to nice discussions - would love to hear what you think!

yarribas.bsky.social•153 days ago

2/ Using RiboSeq and proteomics, we identified a population of translated isoforms containing exonized TEs (JET-ORFs). We propose that these TE-containing isoforms are not “only” merely transcriptional noise but a snapshot of evolving proteins under natural selection.

yarribas.bsky.social•153 days ago

3/ Overall, JETs have been acquired recently during evolution. However, they tend to appear in older, more ancient genes, creating an interesting dichotomy: recent TE-derived exons preferentially integrated into ancient genes.

yarribas.bsky.social•153 days ago

4/ Some JETs show evolutionary conservation, particularly those highly recurrent across samples. Conserved JETs are more frequently used among all splicing isoforms of a gene, and this usage increases across evolution. Thanks to @lquintanamurci.bsky.social and Maxime Rotival for the job!

yarribas.bsky.social•153 days ago

5/ JET-ORFs have defined subcellular locations, which can be different compared to the canonical isoform. Their functions can also differ. Through JET-KOs and splicing modulation, we observed that these functions are biologically relevant at endogenous levels.

yarribas.bsky.social•153 days ago

6/ Structural predictions revealed that TE-derived exons preferentially fold into alpha helices, thanks to their distinct amino acid composition. These exons can boost the alpha-helix content of host proteins, a structural feature that increases during protein evolution.

yarribas.bsky.social•153 days ago

7/ It has been a completely unexpected journey. Starting with the study of cryptic antigens and tumor immunology, we ventured into the unfamiliar territory of protein structure and evolution. It has been an incredible learning experience!

joshwaterfall.bsky.social•152 days ago

Congrats Yago ! Your perseverance really paid off !

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