My main PhD work is now out!
We find that choice of antibiotic and the level of (sub-inhibitory) dose is important for combining with phages. Good combinations reduce resistance evolution and simple antibiotic susceptibility experiments can help us choose
Co-authors not on bsky, brief thread below
We find that choice of antibiotic and the level of (sub-inhibitory) dose is important for combining with phages. Good combinations reduce resistance evolution and simple antibiotic susceptibility experiments can help us choose
Co-authors not on bsky, brief thread below
Reposted from
PLOS Biology
Gram-neg bacteria can resist #phages by modifying their LPS, also affecting #antibiotic susceptibility. @lavishaparab.bsky.social &co show that antibiotic concentrations influence evolution of E. coli phage resistance, leading to enhanced phage-antibiotic synergy 🧪 @plosbiology.org plos.io/4hPmO0X
Comments
The paper changed a lot, but the overall conclusions are similar
I'll try to make an updated thread soon
https://bsky.app/profile/lavishaparab.bsky.social/post/3k6b5o7up2z2q