Since my episode with the wonderful @longcovidanswer has been released highlighting viral persistence as a major driver of some #LongCOVID pathology, I’ve been asked repeatedly, “what should we do about it?” - totally fair question. Here is my proposed roadmap: 1/ - ThreadSky

putrinolab.bsky.social • 43 days ago

Since my episode with the wonderful @longcovidanswer has been released highlighting viral persistence as a major driver of some #LongCOVID pathology, I’ve been asked repeatedly, “what should we do about it?” - totally fair question. Here is my proposed roadmap: 1/

Comments

alisonjones.bsky.social•43 days ago

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cffnthmrnng.bsky.social•43 days ago

My 14y old with very severe #MECFS #LongCovid is asking every couple of weeks how your work on rapamycin is progressing. And if you would let us know as soon as possible if it‘s looking good. 🙏🫶.

roundballnz.bsky.social•43 days ago

📌

witchwei.bsky.social•42 days ago

📌

confounding-y.bsky.social•43 days ago

Great thread. Thank you all for being champions in this space!

writersvoice.bsky.social•42 days ago

I'm pro-vaccine, but I've been dealing for > 18 months with what may be "long vax"--small fiber peripheral neuropathy that appeared after my 4th Covid booster & surged after my 5th. (It's more common than you think.) Could these therapies help that?

jewelwingaudio.bsky.social•33 days ago

I'm a combo long covid (2020) and 'long vax' (2021) reaction and boy am i looking for this info as well!

jillthorburn.bsky.social•43 days ago

Great thread thank you for all you’re doing.

lizardry.bsky.social•43 days ago

📌

martjezingt.bsky.social•43 days ago

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putrinolab.bsky.social•43 days ago

First, let me point out that there are antiviral programs and drugs out there that people have been trying to mixed effects: e.g. Truvada, Maraviroc, Maraviroc + Statins, Valtrex, Valtrex + Celebrex, Paxlovid and various combos of these. This is NOT medical advice or urging 2/

putrinolab.bsky.social•43 days ago

anyone to try these things without knowing your history, but more to say that people are trying them for persistence and the results are mixed. Similarly, there are many monoclonal products that may hold promise on their own and in combo with antivirals: evusheld, aerium, 3/

putrinolab.bsky.social•43 days ago

regencov, etc…but monoclonals are
much harder to access even if you self-pay and many have been shelved by the pharma companies (or the companies no longer exist) because they were designed to treat specific COVID strains that are no longer dominant - which also reminds us 4/

putrinolab.bsky.social•43 days ago

that unless you’re trialing a more broad spectrum monoclonal for #LongCOVID you must be sure to trial one for the SARS-CoV-2 strain that triggered your LC. Finally, if you believe that persistence is occurring, but maybe it is occurring because your immune system is failing to 5/

putrinolab.bsky.social•43 days ago

clear pathogens, then maybe immune modulating therapies may have a role, such as low dose rapamycin, which has been shown in other, non-LC trials to reduce T Cell exhaustion, enhance natural killer cell function and stabilize interferon signaling. There are many other targets 6/

pennyjs.bsky.social•43 days ago

Rapamycin is an mTOR inhibitor. In general terms, is down-regulating mTOR a strategy being studied for long Covid? I’ve been fascinated by mTOR as a possible means of life extension and have a list of other mTOR inhibitors. Would appreciate anything else you could add about the connection here.

medidier.bsky.social•43 days ago

🙏📌

putrinolab.bsky.social•43 days ago

to think about in the world of persistence and even more feasible combinations to consider (watch out for a paper led by the amazing @microbeminded2 on this topic in early Feb) and many of these options are available right now to patients who are able to afford to pay cash. 7/

jpeacejpeace.bsky.social•43 days ago

Have there been any studies/clinical experiences attempting to identify persistent viral infections and employ "matched" monoclonal antibobies to compare this approach to treating with a "more broad spectrum monoclonal"?

randiani.bsky.social•43 days ago

📌

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