In >60,000 UK Biobank participants an association between higher cardiorespiratory fitness (CRF) and less Alzheimer's disease (AD) and dementia during 12-year follow-up, mitigating genetic predisposition (w/high CRF, reduced by 35%) https://bjsm.bmj.com/content/early/2024/10/10/bjsports-2023-108048 open-access; PRS-polygenic risk score