One of the alluring and theoretical strategies for extending healthspan and longevity is to rejuvenate the thymus gland, promote an intact immune system. Now there's a way to do that in aged mice. www.science.org/doi/10.1126/... - ThreadSky

erictopol.bsky.social • 89 days ago

One of the alluring and theoretical strategies for extending healthspan and longevity is to rejuvenate the thymus gland, promote an intact immune system. Now there's a way to do that in aged mice.

https://www.science.org/doi/10.1126/scitranslmed.adp3171

Comments

rupertstubbs.bsky.social•89 days ago

Is the IN MICE Twitter account over here yet?

lyndallterrier.bsky.social•89 days ago

This sounds very promising. Wonderful in fact. But locked full article so I can't see... what is exogenous RANKL treatment (presumably done to live aged mice)? That is, what does it involve (e.g. injection into thymus gland?) and is it using existing drugs & tech but currently off-label?

lyndallterrier.bsky.social•89 days ago

PS - seeing COVID-19 infection exhausts T-Cells and effects our immune systems, this RANKL treatment is just what we need in the world right now.

mtwoltering.bsky.social•89 days ago

I was just wondering exactly the same...

lyndallterrier.bsky.social•88 days ago

I would love to know what A J Leonardi @fitterhappierAJ thinks of this RANKL treatment. But I don't know if he's on BlueSky.

precisionlife.bsky.social•89 days ago

Increasing Healthspan:
Predicting & Preventing Complex Chronic Diseases

https://precisionlife.com/increasing-healthspan

pietroghezzi.bsky.social•89 days ago

Not so easy; anti-RANKL (denosumab) is a treatment for osteoporosis: would administration of RANKL cause bone resorption and osteoporosis?

wmassgal.bsky.social•89 days ago

This is amazing research!

barbtries.bsky.social•89 days ago

I'm 69. How long before they start clinical trials?

ewingt-phd.bsky.social•88 days ago

Great news!

Besides thymic involution, another immunosenescence phenomenon is white bone marrow that produces immune cells converts into yellow bone marrow that stores fat

Bone marrow yellowing

Can’t wait to see whether RANKL might be related…

shorebird.bsky.social•89 days ago

Absolutely incredible!

rtmlepage.bsky.social•89 days ago

Oh, this is interesting!

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