In a very large dataset of people with diabetes treated with GLP-1 drugs cf other medications, there were benefits seen for reduced clotting disorders, seizures, neurocognitive disorders (including Alzheimer's), by @zalaly.bsky.social and colleagues www.nature.com/articles/s41... - ThreadSky

erictopol.bsky.social • 34 days ago

In a very large dataset of people with diabetes treated with GLP-1 drugs cf other medications, there were benefits seen for reduced clotting disorders, seizures, neurocognitive disorders (including Alzheimer's), by @zalaly.bsky.social and colleagues
https://www.nature.com/articles/s41591-024-03412-w

Comments

stacy-jakes.bsky.social•34 days ago

That's fascinating! It’s great to see GLP-1 drugs potentially offering benefits beyond glycemic control. Were there any hypotheses on the mechanisms behind the reduced risk of clotting, seizures, and neurocognitive disorders?

alittlebirdinsocal.bsky.social•34 days ago

There are likely multiple mechanisms, including indirect effects on inflammatory processes such as:

https://www.cell.com/cell-metabolism/fulltext/S1550-4131(23)00420-5

zaisarel.bsky.social•34 days ago

Yeah I'm thinking Nobel

huskify.bsky.social•34 days ago

📌

henningt6.bsky.social•34 days ago

📌

lesleefoley.bsky.social•34 days ago

I've had type one for 54 years. Yes, this is just another drug that type one diabetics cannot take.

chujo.bsky.social•34 days ago

Technically, you can take it, but you'll be forced to pay out-of-pocket for it because insurance companies gleefully refuse to cover it for T1Ds. I was put on a GLP-1 drug for issues outside my T1D, and after 6 months, my A1C has dropped by almost a point & a half to the lowest it's been in 20 years

lesleefoley.bsky.social•34 days ago

It's not approved for type one diabetics by the food and drug administration. Therefore, my doctor will not prescribe it for me.

chujo.bsky.social•34 days ago

Yeah, that's the excuse insurance companies are using not to pay for it. The fact the FDA hasn't approved it (much less researched it) for T1D by this point is unconscionable.

lilyflagg.bsky.social•34 days ago

I didn't know that. 😓

sowelldtx.bsky.social•34 days ago

I'm not particularly overweight, and am in generally good health. However, I would like all of the benefits of of GLP-1s, WITHOUT the loss of muscle mass (and nausea/vomiting, etc). Will there be a solution that provides this outcome?

scottleibrand.bsky.social•34 days ago

It’s still early days, but some people are experimenting with microdosing them. Your doctor could prescribe you a lower dose or slower ramp-up if they thought that appropriate for your situation.

jhsu802701.bsky.social•34 days ago

1. Consume a high-fiber Mediterranean/DASH/MIND diet. You can rely on the dietary fiber, protein, and healthy fats to satisfy your appetite. Your weight will largely take care of itself.
2. Wait for summer. The warmer months bring a smaller appetite and more chances to exercise.

erictopol.bsky.social•34 days ago

The abstract of the paper and the risks seen vs other meds for Type 2 diabetes

darlingultra.bsky.social•33 days ago

📌GLP-1

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