For me, it was Assassin's Creed IV. I didn't care too much for the Ezio trilogy. Though I still liked them. The worst in the series was Liberation. Didn't care much for the first one either. Though I played the first game long after the others, so that's probably why.
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JOKING!!! I love Brotherhood!!! I just feel that ACII really set the tone and brought so many people into the series😊