It would be fascinating to perform statistical design of experiments and determine the main effects on product yield and reduce the 2.5 equivalents of the often expensive aryl acetic acid. I also wonder if quinoline would catalyze this. #organicchemistry #synthesis
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The condensation of 2-nitrobenzyl alcohols with arylacetic acids provides substituted quinazolines under mild conditions
The condensation of 2-nitrobenzyl alcohols with arylacetic acids provides substituted quinazolines under mild conditions
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