The brachyury structure, along with crystallographic fragment-based screening and enhanced compounds, may enable the development of chemical probes and future drugs. This approach could also be applied to other hard-to-drug transcription factors and proteins.
Reposted from The Institute of Cancer Research
ICR's Professor Paul Workman, and researchers at @ox.ac.uk and @uncchapelhill.bsky.social have made a breakthrough that could lead to drugs for the 'undruggable' chordoma - the rare #BoneCancer that killed Paul's mother.

Read more from Professor Workman here ⬇️
www.icr.ac.uk/research-and...

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