Here we describe development a SunTag based tool for H3K4me3 deposition, and use it to activate endogenous genes, improve pathogen resistance and unlock meiotic crossovers at centromeric regions in Arabidopsis.
A huge enormous thank you to collaborators @hendersi.bsky.social – amazing to share lab space with this guy! and Steve Jacobsen who was involved at the inception and for supporting me to develop this work in my own group.
Also would like to give a big shout out to @jamiehackett.bsky.social and colleagues - we were inspired by their amazing work, and without it would not have discovered that using mammalian PRDM9 is highly efficient with reduced off target!
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