Last play through, I waited right for the end game to do it. Dog Eat Dog, Meet Hanako at Embers were my last 2 quests, lol.
BUT
This play through I'm doing it quite a bit earlier. Mid act 2. A bit after the Heist, you get The Big Three Act 2 quest lines. Judy, Panam, and Takemura. I've done+
I always say knock out the start of it early on, because it gets you some cool upgrades for the arm slot stuff, Mantis Blades & etc, that add to the combat experience. If you wanna fully commit to PL's story though doing it last is good too, the story is really good.
Comments
BUT
This play through I'm doing it quite a bit earlier. Mid act 2. A bit after the Heist, you get The Big Three Act 2 quest lines. Judy, Panam, and Takemura. I've done+
Narratively, my V grasping at straws for a fix, and I plan to mix up PL with the other big Act 2 gigs.
Mechanically, you get a lot of good loot from PL. Wait too long, and you won't have much game left to enjoy it!