Turns out AF-Cluster does not sample different evolutionary couplings. The prediction of fold-switched states is likely due to AF2 memorisation of its training set www.nature.com/articles/s41... - ThreadSky

jameslingford.bsky.social • 69 days ago

Turns out AF-Cluster does not sample different evolutionary couplings. The prediction of fold-switched states is likely due to AF2 memorisation of its training set
https://www.nature.com/articles/s41586-024-08267-2