For cancer awareness I never understood this: yes, there r mutated cells, but the origin/source? “all cells of the organism are exposed to the carcinogen. From a developmental biology perspective, the ? is, which is the target of the carcinogen: the epithelium, the stroma or both?” #cancer #fightCRc
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Eric Topol
Quite an essay on the basis of cancer entitled "The End of the Genetic Paradigm of Cancer" @plosbiology.org arguing against the primacy of somatic mutations (traditional model) and cells, invoking gene regulatory networks and tissue
journals.plos.org/plosbiology/...
journals.plos.org/plosbiology/...
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