⛔️Press release⛔️ Phase 2b Study of Oral Omadacycline M. abscessus Pulmonary Disease ➡️ 1st placebo RCT M.abscessus ➡️ Sx-based endpoints = 👍 ➡️ Microbiologic endpoints = higher conversion (-) culture, no R ➡️ 12w, omadacycline safe & well-tolerated #IDsky www.globenewswire.com/news-release... - ThreadSky

sebpoule.bsky.social • 119 days ago

⛔️Press release⛔️

Phase 2b Study of Oral Omadacycline M. abscessus Pulmonary Disease

➡️ 1st placebo RCT M.abscessus

➡️ Sx-based endpoints = 👍

➡️ Microbiologic endpoints = higher conversion (-) culture, no R

➡️ 12w, omadacycline safe & well-tolerated

#IDsky

https://www.globenewswire.com/news-release/2024/11/08/2977671/0/en/Paratek-Pharmaceuticals-Announces-Positive-Top-Line-Data-from-Phase-2b-Study-of-Oral-Omadacycline-OMC-in-Nontuberculous-Mycobacterial-NTM-Abscessus-Pulmonary-Disease.html

Comments

catherineberry.bsky.social•119 days ago

It's a NTM sort of day. Be nice to be rid of tigecycline.

paulsaxmd.bsky.social•119 days ago

Huge if this eventually pays off with an FDA approval. Just huge.

bryanpwhite.bsky.social•118 days ago

I hope they do the phase 3 trial. Getting it for patients on Medicare is difficult now.

drrossanarosa.bsky.social•119 days ago

This is great! Now to get it in the Canadian market, different story…

sebpoule.bsky.social•119 days ago

Congratulations!

You are now officially a 100% 🇨🇦 I.D. Doc;

➡️You get cynical with « new »antibiotics availability 😂

drrossanarosa.bsky.social•119 days ago

LOL yeah… managed to get clofa for a pt because it’s provided by Novartis, but omadacycline (if priced as in the US) would be impossible to pay for (unless you’re a millionaire)

pjlillie.bsky.social•118 days ago

It gets mentioned reasonably frequently in the national NTM / MDR-TB forum in the UK but no one seems to have got hold of it. Have a few really tricky M.abscessus cases that I’d love to have it available for, hope this nudges the company re availability….

tomayates.bsky.social•65 days ago

Do we know what the background regimen was in this trial? The press release reads as if it were given as a single agent, which seems unlikely.

pjlillie.bsky.social•65 days ago

Don’t know, wonder if it was added to an optimised background regimen like the old trials in hiv salvage

brainofbpharm.bsky.social•119 days ago

Now if only PO omada wasn’t prohibitively expensive for patients even AFTER insurance coverage!

I’ve actually had patients go out on IV 💉 because their medical benefits pick up much more of the costs.

asato4kids.bsky.social•119 days ago

Reminds me of linezolid pricing

brainofbpharm.bsky.social•119 days ago

It definitely seems like use took off once it went generic.

kelliepharmd.bsky.social•119 days ago

And omada won’t be generic until 2028 at the earliest 🫤

juliambisome.bsky.social•119 days ago

Absolutely ridiculous this is the case. Our healthcare needs so much work 😓

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