Takahiro Sakamoto used a creative approach to derive the threshold per-trait mutation rate where local adaptation shifts from a stable to transient genetic architecture. The prevalanece of stable architectures in nature implies small mutational target size
https://academic.oup.com/genetics/advance-article/doi/10.1093/genetics/iyae165/7819852?utm_source=advanceaccess&utm_campaign=genetics&utm_medium=email