📢 Excited to share our new paper out today in Nature Neuroscience! 🧠✨ We uncover how compartmentalized dendritic plasticity in the retrosplenial cortex (RSC) links contextual memories formed close in time. A thread 🧵👇 [1/8] nature.com/articles/s41... - ThreadSky

meghasehgal.bsky.social • 87 days ago

📢 Excited to share our new paper out today in Nature Neuroscience! 🧠✨

We uncover how compartmentalized dendritic plasticity in the retrosplenial cortex (RSC) links contextual memories formed close in time. A thread 🧵👇 [1/8]

https://nature.com/articles/s41593-025-01876-8

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meghasehgal.bsky.social•87 days ago

1/ 🧩 Key Finding: Memories formed close in time are linked through overlapping RSC ensembles and branch-specific dendritic plasticity. This mechanism helps integrate related experiences. [2/8]

meghasehgal.bsky.social•87 days ago

2/⏰ Neuronal Allocation: Using UCLA Miniscopes
@MiniscopeTeam and activity-dependent tagging, we showed that RSC neuronal overlap is important for linking memories formed close in time [3/8]

meghasehgal.bsky.social•87 days ago

3/🧠 Dendritic Allocation: We then used 2-photon imaging to show that the same dendritic segments are activated during encoding of 2 linked memories and spine clusters are formed on the same dendritic branches➡️memory linking results in branch-specific dendritic plasticity [4/8]

meghasehgal.bsky.social•87 days ago

4/ 💡 Causal Evidence: Using a novel method to tag and reactivate recently active dendritic compartments: Optogenetic reactivation of these dendrites was sufficient to link two independent memories ➡️ compartmentalized dendritic plasticity is important for memory integration [5/8]

meghasehgal.bsky.social•87 days ago

5/ 🧬 Using computational modeling, we found that dendritic plasticity is necessary for memory linking. Removing dendritic mechanisms in the model abolished co-recall of linked memories. [6/8]

meghasehgal.bsky.social•87 days ago

6/ 🌟 TLDR: We show that compartmentalized dendritic plasticity can influence future dendritic plasticity, memory formation and integration. [7/8]

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