For those in the field, look at our latest review article on: "Amphetamine and methylphenidate potential on the recovery from stroke and traumatic brain injury: a review" www.degruyter.com/document/doi... #PharmSky #ToxSky #MedSky #NeuroSky 🧪 - ThreadSky

jpcapela.bsky.social • 99 days ago

For those in the field, look at our latest review article on:
"Amphetamine and methylphenidate potential on the recovery from stroke and traumatic brain injury: a review"

https://www.degruyter.com/document/doi/10.1515/revneuro-2024-0016/html

#PharmSky
#ToxSky
#MedSky
#NeuroSky
🧪

Comments

theidealhuman.bsky.social•99 days ago

Well to look at stimulants for neuroprotection and cardioprotection is extremely contra narrative.
Color me highly skeptikal but +1 for originality.

jpcapela.bsky.social•99 days ago

Thanks for your interest in our work. In fact regarding the brain it makes sense the use of stimulants for this neurological disorders. In particular methylphenidate, that is used to treat ADHD, has been given more attention for stroke or TBI.

theidealhuman.bsky.social•99 days ago

I don't see how it particularly makes sense.
Stims can be a symptomatic palliative in some TBIs.
But adrenaline should be a brain vasoconstrictor which is iirc contra indicated contrary to e.g. gingko biloba or vimpocetine.
Adrenergy is one of the most well known cardiotoxin. Dopamine is neurotoxic

theidealhuman.bsky.social•99 days ago

2) to be clear:
stimulants can be useful as a palliative and as a neuroprotective.
It might even cause some neurogenesis but it should never the less be cardiotoxic and moderately neurotoxic
https://pubmed.ncbi.nlm.nih.gov/37000398/

theidealhuman.bsky.social•99 days ago

4) https://pubmed.ncbi.nlm.nih.gov/37991787/

theidealhuman.bsky.social•99 days ago

3) as a nootropic not as a neuroprotectant* made a typo

jpcapela.bsky.social•99 days ago

I understand your concerns regarding the cardiovascular adverse effects, which no doubt should be given attention. The clinical trails did not show that adverse effects under control doses and settings were a problem. They did reveal mixed results, some improved others detailed no improvement.

sally-ann-cole.bsky.social•99 days ago

OK; how to you deal with effects on neuroinflammation, neurotoxicity and oxidative damage & BBB disruption. Presumably you are talking about therapeutic levels for ADHD or lower?

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jpcapela.bsky.social•99 days ago

Thanks for your interest. Bit amphetamine and methylphenidate are used in ADHD. So in controlled doses and settings they can be therapeutically useful. The major problem with these two drugs are cardiovascular, and trials reveal no major adverse effects that could undermine its use.

sally-ann-cole.bsky.social•98 days ago

I didn’t say it to undermine it - I said it to have discussion

sally-ann-cole.bsky.social•98 days ago

Yes I know

Long term effects of efficacious doses for ADHD at different ages on neuroinflammation, oxidative damage & neurodegeneration are not well studied.

I haven’t looked at the dosing used in the animal studies using human - rodent extrapolation to determine how m relevant it is

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