Researchers from MD Anderson Cancer Center & Fred Hutch Cancer Center have uncovered how genome-wide hypertranscription, a hallmark of many cancers, may drive tumor progression & predict poor prognosis
https://www.science.org/doi/10.1126/science.ads2169
#CancerResearch #PrecisionOncology #Hypertranscription #Genomics
https://www.science.org/doi/10.1126/science.ads2169
#CancerResearch #PrecisionOncology #Hypertranscription #Genomics
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-Using an innovative FFPE-RNAPII mapping method, global RNA polymerase II (RNAPII) elevations were observed in human tumors and mouse gliomas.
-Regional RNAPII increases corresponded to HER2 amplifications and chromosome losses in cancers.
-Suggests that histone hypertranscription may be critical for cancer cell overproliferation.
@mdanderson.bsky.social @fredhutch.bsky.social