Our new paper, using shotgun metagenomics on the gut microbiome, shows small but interesting longitudinal changes with age in a natural population. 🧵1/5 academic.oup.com/ismecommun/a... - ThreadSky

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chuenlee.bsky.social • 8 days ago

Our new paper, using shotgun metagenomics on the gut microbiome, shows small but interesting longitudinal changes with age in a natural population.

🧵1/5

https://academic.oup.com/ismecommun/article/5/1/ycaf008/7976665

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chuenlee.bsky.social•8 days ago

In our recent paper on the gut microbiome with age and senescence, we used a longitudinal dataset of the Seychelles warbler (Acrocephalus sechellensis) to show that the gut microbiome diversity reduces with age in taxonomy and function.

🧵 2/5

chuenlee.bsky.social•8 days ago

Importantly, these reductions in GM diversity were within-individual, meaning that they were reducing within the same individual and not a result of selective disappearance. We also show a small change in taxonomic and functional composition with age.

🧵 3/5

chuenlee.bsky.social•8 days ago

Interestingly, we also found a group of gut microbiome transposase genes that were increasing in abundance with age and this group of transposase genes was not associated with an increase in abundance of a specific bacterial taxa.

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chuenlee.bsky.social•8 days ago

Given the reduction in GM diversity, why would the gut microbiome transposase genes increase with host age?

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chuenlee.bsky.social•8 days ago

A huge thank you to everyone involved in this project ❤️
Sarah Worsley, @charlisdavies.bsky.social , Ece Silan, @terryburke.bsky.social , Jan Komdeur, @bioinf.bsky.social, @hannahdugdale.bsky.social , David S. Richardson

@seychelleswarbler.bsky.social
@uniofeastanglia.bsky.social
NRPDTP

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