L-Citrulline Supplementation Increases Plasma Nitric Oxide Levels and Reduces Arginase Activity in Patients With Type 2 Diabetes #citrulline #ARG1 #ARG2 #MECFS #LongCovid
https://pubmed.ncbi.nlm.nih.gov/33414716/
https://pubmed.ncbi.nlm.nih.gov/33414716/
Comments
"Reduced availability of L-arginine to eNOS has been implicated in vascular dysfunction in diabetes."
"Arginase, which metabolizes L-arginine to urea and ornithine, competes directly with NOS for L-arginine."
"Hence, increases in arginase activity can decrease arginine levels, reducing its availability to eNOS and decreasing NO production."
"Diabetes has been linked to elevated arginase and associated vascular endothelial dysfunction."
"We aimed to determine levels of plasma NO and arginase activity in (T2DM) patients and the effects of L-citrulline supplementation, a natural arginase inhibitor, on inhibiting arginase activity in these patients."
"Levels of arginase correlated with HbA1c levels in diabetic patients."
"Twenty-five patients received L-citrulline supplements (2000 mg/day) for 1 month."
"Arginase activity decreased by 21% in T2DM patients after taking L-citrulline supplements."
"Additionally, plasma NO levels increased by 38%."