Serological data provide key insights on pathogen circulation. We introduce a new R package, Rsero, which is a pipeline to store and analyze age-stratified sero data, estimate the history of pathogen circulation and compare different transmission models. journals.plos.org/ploscompbiol... - ThreadSky

scauchemez.bsky.social • 21 days ago

Serological data provide key insights on pathogen circulation. We introduce a new R package, Rsero, which is a pipeline to store and analyze age-stratified sero data, estimate the history of pathogen circulation and compare different transmission models.
https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1012777

Comments

divyav.bsky.social•20 days ago

📌

scauchemez.bsky.social•21 days ago

Rsero can help you determine if your data are more consistent with a scenario of endemic ‘constant’ circulation, or with the occurrence of 1, 2 or 3 outbreaks in the last 50 years. It can estimate the year when these outbreaks occurred.

scauchemez.bsky.social•21 days ago

Rsero can assess how infection risk may vary with individual characteristics, e.g. gender and location.

scauchemez.bsky.social•21 days ago

You can also use Rsero to evaluate the impact of interventions, here mass drug administration on Trachoma prevalence in Nepal.

scauchemez.bsky.social•21 days ago

Rsero is useful to determine optimal designs for serosurveys depending on context. For example, should you target the general population, children <10y.o. or <20y.o.? This will depend on the expected annual probability of infection (FOI)...

scauchemez.bsky.social•21 days ago

Simplicity is a key strength of the package: it only takes a few lines of code to run and compare different types of models! Dev by Nathanael Hoze, with contributions from Marga Pons, @jessmetcalf.bsky.social, @mtwhite.bsky.social, @hsalje.bsky.social.

tah-sci.com•14 days ago

Cool! Have you considered synergies with the "Epiverse" that @cmmid-lshtm.bsky.social is pulling together? They organised a great workshop to look at collation and documentation of these kinds of tools last week. https://epiverse-trace.github.io/

Comments

Posting Rules

Reply