Really excited this is out! We found polyunsaturated fatty acids (PUFAs) were beneficial in models of C9orf72 FTD/ALS and the greatest benefit occurred when increasing levels specifically within neurons @ukdri.ac.uk @uclqsion.bsky.social @ucl.ac.uk @cziscience.bsky.social rdcu.be/ebbZf - ThreadSky

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Really excited this is out! We found polyunsaturated fatty acids (PUFAs) were beneficial in models of C9orf72 FTD/ALS and the greatest benefit occurred when increasing levels specifically within neurons @ukdri.ac.uk @uclqsion.bsky.social @ucl.ac.uk @cziscience.bsky.social
https://rdcu.be/ebbZf

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junjieguo.bsky.social•1 day ago

Congratulations Adrian and the team!

adrianisaacs.bsky.social•1 day ago

We initially found a deficit in PUFAs in C9orf72 patient neurons and a fruit fly model by measuring ~1400 different lipids with Martin Giera and @rikvanderkant.bsky.social

adrianisaacs.bsky.social•1 day ago

We next wanted to test if restoring PUFAs would be beneficial. We found that increasing PUFAs through the diet only modestly extended survival of our C9orf72 ALS fly model

adrianisaacs.bsky.social•1 day ago

So we next expressed a fatty acid desaturase enzyme, which generate PUFAs, only in the brain cells of our C9orf72 ALS flies and this time the improvement was much more dramatic. This approach also increased the survival of human C9orf72 patient neurons

adrianisaacs.bsky.social•1 day ago

This suggests that delivery of PUFAs to neurons in the brain is needed for them to exert their protective effect

adrianisaacs.bsky.social•1 day ago

Our data fits well with existing epidemiological studies from Alberto Ascherio @hsph.harvard.edu showing increased PUFA levels reduces risk for ALS and prolongs survival after onset e.g https://jamanetwork.com/journals/jamaneurology/fullarticle/1886776

adrianisaacs.bsky.social•1 day ago

We next need to determine whether a specific PUFA (there are several) is able to provide benefit on its own and then take forward to a clinical trial

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