"Highly infectious viruses such as the human immunodeficiency virus (HIV), Ebola virus, or hepatitis C virus encode proteins that function as ion channels."
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It is Tat that contributes to hippocampal atrophy and the calcium overload observed above.
HIV-1 protein Tat induces apoptosis of hippocampal neurons by a mechanism involving caspase activation, calcium overload, and oxidative stress https://pubmed.ncbi.nlm.nih.gov/9878167/
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HIV-1 protein Tat induces apoptosis of hippocampal neurons by a mechanism involving caspase activation, calcium overload, and oxidative stress https://pubmed.ncbi.nlm.nih.gov/9878167/