Our overarching aim is to reveal the mechanisms that control fat mass and body weight. We use a mouse model of overfeeding to create energy imbalance and observe the natural response to overfeeding. In this study we focused on energy expenditure and excretion changes (2/n) - ThreadSky

pranea.bsky.social • 44 days ago

Our overarching aim is to reveal the mechanisms that control fat mass and body weight. We use a mouse model of overfeeding to create energy imbalance and observe the natural response to overfeeding. In this study we focused on energy expenditure and excretion changes (2/n)

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pranea.bsky.social•44 days ago

Overfeeding causes a robust decrease in food intake (this we knew), but also an adaptive increase in energy expenditure that is subtle with this duration of overfeeding. After overfeeding, the profound reduction in food intake seems to be the major driver of the recovery in body weight. (3/n)

pranea.bsky.social•44 days ago

We also explored the role of adipose tissue thermogenesis, which is the process of heat generation in fat. UCP1 KO mice behaved similarly to wild-type mice when subjected to overfeeding at 22ºC. (4/n)

pranea.bsky.social•44 days ago

Gene expression analysis in metabolic tissues revealed some interesting changes in transcriptional programs related to futile cycles (body using energy somehow like the guy in the GIF below), but the impact of these changes in the response to overfeeding remains to be determined. (5/n)

pranea.bsky.social•44 days ago

What if part of the energy is being excreted during/after overfeeding? Well, fecal energy excretion actually decreased in response to overfeeding (at least during recovery)! Probably related to the fact that they are eating less (6/n)

pranea.bsky.social•44 days ago

Overall, this study provides new insights into the body's complex response to overfeeding. The ability to regulate food intake seems to be the primary defense against weight gain in mice. We are still very intrigued by the biological mechanisms behind this response! (7/n)

pranea.bsky.social•44 days ago

More research is needed to see if these findings apply to humans, but it offers relevant knowledge to better understand how our bodies respond to a calorie surplus. There is time-resolved energy expenditure data during and after overfeeding for the first time! (8/n)

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