1/ Leveraging the recently introduced Orbitrap-Astral mass spectrometer, we measured the plasma proteomes of >3,000 individuals aged 5-20 in the HOLBAEK Study, quantifying >1,000 proteins per sample at 60 SPD throughput.
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2/ We used multiple linear regression to assess the impact of age, sex, and BMI-SDS on the plasma proteome, finding 58% of the proteins associated with at least one factor according to the data and our modeling. Plasma proteins in turn also predicted age and BMI.
3/ We highlight intriguing protein abundance trajectories through puberty, including sex hormone-related differences and key bone development proteins linked to growth plate closure during skeletal maturation, reflecting the sex differences in onset of puberty.
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