2/ We used multiple linear regression to assess the impact of age, sex, and BMI-SDS on the plasma proteome, finding 58% of the proteins associated with at least one factor according to the data and our modeling. Plasma proteins in turn also predicted age and BMI. - ThreadSky

mannlab.bsky.social • 12 days ago

2/ We used multiple linear regression to assess the impact of age, sex, and BMI-SDS on the plasma proteome, finding 58% of the proteins associated with at least one factor according to the data and our modeling. Plasma proteins in turn also predicted age and BMI.

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mannlab.bsky.social•12 days ago

3/ We highlight intriguing protein abundance trajectories through puberty, including sex hormone-related differences and key bone development proteins linked to growth plate closure during skeletal maturation, reflecting the sex differences in onset of puberty.

mannlab.bsky.social•12 days ago

4/ We tested 5.2 million SNPs for effects on plasma protein levels, leveraging peptide-level information to classify pQTLs by confidence and remove “epitope effect” artifacts. We also examined how technical factors such as CV and protein properties influence pQTL detection.

mannlab.bsky.social•12 days ago

5/ Plasma protein levels are influenced by various factors, but the degree varies from protein to protein. Through variance decomposition we found that some proteins are mainly influenced by genetic variants, while others are shaped by factors like age and obesity.

mannlab.bsky.social•12 days ago

6/ Using identified cis-pQTLs as genetic instruments, we performed systematic Mendelian randomization and colocalization analyses, identifying candidate causal genes for cardiometabolic traits across five therapy areas.

mannlab.bsky.social•12 days ago

7/ We replicated pQTLs in 1,000 children and adolescents and 558 adults from an independent cohort of alcohol-related liver disease. We further explored whether integrating pQTLs could influence biomarker performance which indeed proved to be the case.

mannlab.bsky.social•12 days ago

8/ Finally, we provide an interactive web portal for exploring the results at https://pqtl.org.

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