1) That's not really a simple question :-). Obviously the video is a few years old and relates (largely) to "novel" discoveries and techniques that have long since become part of mainstream science. But if you are asking whether the science described has been fundamentally superseded? .....
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I suppose the big change since Wilson's day is our growing realization that the *regulation* of (protein-coding) genes is as (or more) important than what (p-c) genes we have. (And we used to think that "gene" and "protein coding gene" were more or less synonyms.)
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"Cavalli-Sforza had published a paper with Doug Wallace saying that Asia is the origin. Other people, like Wolpoff in Michigan, were arguing that the mitochondrial trees couldn't possibly ever be right, ...."
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https://pmc.ncbi.nlm.nih.gov/articles/PMC2877732/
"Gene" means it is hard to tell what this sequence will eventually do or look like.
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