1/ 🎙️ Episode 6 of The Long COVID Clinical Podcast explores Myalgic Encephalomyelitis/Chronic Fatigue Syndrome #MECFS and its parallels with Long COVID. Dr. Hector Bonilla shares clinical insights, pathophysiology, & treatment strategies. #MedSky #LongCOVID open.spotify.com/episode/4aJt.... 🧵 - ThreadSky

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cjchiu.bsky.social • 51 days ago

1/ 🎙️ Episode 6 of The Long COVID Clinical Podcast explores Myalgic Encephalomyelitis/Chronic Fatigue Syndrome #MECFS and its parallels with Long COVID. Dr. Hector Bonilla shares clinical insights, pathophysiology, & treatment strategies. #MedSky #LongCOVID
https://open.spotify.com/episode/4aJtxzV5h5BzDPaYzDKw8p. 🧵

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cjchiu.bsky.social•51 days ago

2/ 🩺 ME/CFS is a complex, often misunderstood condition. Its symptoms—fatigue, brain fog, unrefreshing sleep, orthostatic intolerance, and post-exertional malaise—overlap with Long COVID. 50% of Long COVID patients fit ME/CFS criteria.

cjchiu.bsky.social•51 days ago

3/ 🔬 Dr. Bonilla highlights shared viral triggers: SARS-CoV-2, Epstein-Barr, and other infections can lead to post-viral syndromes. Long COVID isn’t new—similar patterns followed SARS (2002) and MERS (2012).

cjchiu.bsky.social•51 days ago

4/ 🧪 Pathophysiology: Persistent viral antigens, immune dysregulation, mitochondrial dysfunction, and inflammation drive symptoms. Research is ongoing to uncover biomarkers for diagnosis and treatment.

cjchiu.bsky.social•51 days ago

5/ ⛽ "Think of energy like a gas tank," says Dr. Bonilla. ME/CFS & Long COVID patients operate on "2 gallons" instead of 40. Pacing is critical to avoid crashes and manage daily life.

cjchiu.bsky.social•51 days ago

6/ 💊 Treatment insights:

- Low-dose naltrexone: Reduces inflammation and modulates the immune system.
- Abilify (aripiprazole): May reduce brain inflammation and improve energy regulation. Start with very low doses (0.1-2 mg) and titrate carefully.

cjchiu.bsky.social•51 days ago

7/ 📊 Early data shows ~50% of patients benefit from low-dose naltrexone, and ~70% report positive effects from Abilify. Controlled trials are urgently needed to confirm these findings.

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