1/7: Proud to present our next study on aging microbiome - a massive experimental effort led by the Rosenstiel and Sommer labs and contributions by @sci-witch.bsky.social. @uni-kiel.de @crc1182.bsky.social microbiomejournal.biomedcentral.com/articles/10.... - ThreadSky

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kaletalab.bsky.social • 51 days ago

1/7: Proud to present our next study on aging microbiome - a massive experimental effort led by the Rosenstiel and Sommer labs and contributions by @sci-witch.bsky.social. @uni-kiel.de @crc1182.bsky.social https://microbiomejournal.biomedcentral.com/articles/10.1186/s40168-025-02089-8

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kaletalab.bsky.social•51 days ago

Happy to tag Felix Sommer, lead author on the paper, who recently joined BlueSky: @microbiomefxn.bsky.social

kaletalab.bsky.social•51 days ago

2/7: We explored how continuous transfer of a young microbiome can delay aging processes in mice. Thus, we treated aging mice with recurrent fecal microbial transfers from young donors (yMB) versus transfers from age-matched controls (iMB) —aiming to rejuvenate the gut ecosystem over the lifespan.

kaletalab.bsky.social•51 days ago

3/7: Mice receiving the young microbiome showed improved coordination, a stronger intestinal barrier, and reduced markers of inflammaging compared to controls.

kaletalab.bsky.social•51 days ago

4/7: A multi-omics approach revealed shifts in metabolic pathways, with boosted oxidative phosphorylation and lower pro-inflammatory signals in key intestinal cells.

kaletalab.bsky.social•51 days ago

5/7: Thus, the microbiome-driven decline of microbiome-dependent function that we reported previously seems to be partially reversible upon microbiome rejuvenation. https://www.nature.com/articles/s41564-025-01959-z

kaletalab.bsky.social•51 days ago

6/7: These findings highlight the potential of microbiome-based interventions to extend healthspan and combat age-related decline.

kaletalab.bsky.social•51 days ago

7/7: Also it is important to note some limitations of this work such as the emergence of antibiotic resistance that made microbiome rejuvenation less efficient at later time points.

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