Saying goodbye is hard! So is interpreting non-coding variants in visual disorders! Luckily, that is the gift that Dr. Leah VandenBosch left us with after a very successful postdoc in the Cherry Lab. Check your own favorite retinal regulatory variants here: http://genome.ucsc.edu/s/CherryLab/csVISIONS_TrackHub
Comments
1) Interpretable models trained on scATAC are accurate and cell-class-specific.
2) Models identify emergent features of enhancers such as putative TF binding motifs.
3) Variant Impact Prediction scores allow quick prioritization of retinal disease associated regulatory variants.