Activation of EGFR signaling --> activates annexin A1 and STAT3 --> mobilises matrix metalloproteinase MMP-2/9 --> damages the blood-brain barrier.
The effect can be recapitulated with serum from dialysis patients, and blocked by EGFR inhibitors.
The effect can be recapitulated with serum from dialysis patients, and blocked by EGFR inhibitors.
Reposted from
Professor Lesley Hoyles
Transcriptome-based analyses of mouse brain tissue showed pCS affected lots of different things, but didn't highlight any specific pathway to look at, so @drsimonmcarthur.bsky.social hit the literature and found pCS interacted with EGFR. So this became the focus of his mechanistic work.
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