No it can never happen. I ended up competitive and addicted to Animal Crossing to the detriment of my own health, if Pokemon was included I think it might go horribly for me D:
I think a more likely scenario would be something like the sanrio villiagers where they are clear connections to pokemon, but not the pokemon itself in game or a whole pokemon ac-like
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this is lovely btw!
I would try any potion I trust them with my life