This is really excellent news, and, as the article points out, evidence has been accruing that even a single dose of HPV vaccine may be enough for durable and highly effective prevention of cervical cancer. www.statnews.com/2025/04/28/h... - ThreadSky

enirenberg.bsky.social • 38 days ago

This is really excellent news, and, as the article points out, evidence has been accruing that even a single dose of HPV vaccine may be enough for durable and highly effective prevention of cervical cancer.

https://www.statnews.com/2025/04/28/hpv-vaccine-single-dose-prevents-infection-just-as-well-as-two-doses-hci-clinical-trial/

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poohbearcorner.bsky.social•37 days ago

Cervical cancer is a lifestyle choice for MAGA ANTIVAX people.

kazubelg.medsky.social•38 days ago

Oh, thank G-d! I got pregnant before my 2nd shot and then forgot to finish it!

unicorntickles.bsky.social•38 days ago

Oh nice cause I only ever got like one or two doses and just forgot the rest.

enirenberg.bsky.social•38 days ago

One important limitation here is that we currently only have the summary data from the meeting so it's difficult to assess the study in detail, but it did look only at cervical cancer. While this is CRITICALLY important because cervical cancer is a devastating illness...

enirenberg.bsky.social•38 days ago

HPV is also responsible for oropharyngeal, penile, vulvar, vaginal, anal, and possibly other cancers, as well as genital warts, and recurrent respiratory papillomatosis. To the best of my knowledge, we do not currently have data on how well a single dose of HPV vaccine prevents these conditions.

enirenberg.bsky.social•38 days ago

However, based on the mechanism of action by which the HPV vaccine is thought to achieve such exceptional durability and the specific virological properties of HPV (namely, that it takes hours to enter cells), I would expect that a single dose would be similarly effective.

enirenberg.bsky.social•38 days ago

The less pleasant aspect of the article is... this. It is one of our greatest public health catastrophes that vaccines have managed to become politicized. Needless to say, Kennedy should be impeached as HHS Secretary and it's unconscionable that he was ever considered to hold the job at all.

bcwbcw.bsky.social•38 days ago

If the Democrats regain the House and Senate, they should perhaps go after an impeachment of RFK first as he does not hold a threat over Senate Republicans and some might actually go for it.

djgiantrobot.bsky.social•38 days ago

It will be interesting to see if there’s any impact on cross-type protection, too.

Also, while Lowy at NCI was certainly a key inventor of the vaccine, there were 3 other labs who contributed independently: Georgetown, the University of Rochester, and the University of Queensland.

enirenberg.bsky.social•38 days ago

There is some cross-protection but it is not consistent:
https://www.sciencedirect.com/science/article/abs/pii/S0264410X20315644

djgiantrobot.bsky.social•38 days ago

Oh, thanks! The argument would have been a second dose boosted titers, potentially helping to reach thresholds for cross-types.

That was GSK’s rationale to include a TLR4 agonist adjuvant, which is the bivalent vaccine in this review, vs the 4(+5) Merck vaccine on alum.

More antigens wins!

brenard9.bsky.social•37 days ago

GET IT!!!

dalupton.bsky.social•38 days ago

The mass HPV vax program in Australia for adolescents has been very successful

ff-preobrazhensky.bsky.social•38 days ago

Quite ... https://www.theguardian.com/australia-news/2023/feb/02/australia-on-track-to-eliminate-cervical-cancer-by-2035-amid-rising-hpv-vaccination-rates

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