However, there are a few scenarios where, exceptionally, it has been accepted in the literature that it may not be feasible/essential for a DMC to be set up. These were described in the DAMOCLES project which reviewed all aspects of DMCs 5/8
https://www.journalslibrary.nihr.ac.uk/hta/HTA9070
https://www.journalslibrary.nihr.ac.uk/hta/HTA9070
Comments
patients would all accrue before the DMC could provide input, where there are only v minor hazards from the treatments eg administrative studies & trials aimed at demonstrating a biologic principle 6/8
https://journals.sagepub.com/doi/epdf/10.1191/1740774504cn004rr