While SCN cells connect as a #smallworld network with most cells signaling proximally; intriguingly, we found a few long-range connections from ventral cells that project halfway > across the SCN, short-circuiting the network to enhance signal transmission. (5/n) - ThreadSky

circatwenty4.bsky.social • 58 days ago

While SCN cells connect as a #smallworld network with most cells signaling proximally; intriguingly, we found a few long-range connections from ventral cells that project halfway > across the SCN, short-circuiting the network to enhance signal transmission. (5/n)

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circatwenty4.bsky.social•58 days ago

Two asymmetrically coupled cellular networks drive SCN synchrony: Within each explant, we found dorsal and ventral cellular modules resembling the anatomical shell-core regions. Notably, these were absent in explants that failed to synchronize during our experiments. (6/n)

circatwenty4.bsky.social•58 days ago

The SCN exhibited strong ventral-to-dorsal signaling, with over 60% of all connections originating from ventral cells. Accordingly, ventral module cells synchronize their rhythms first, driving the rest of the network. (7/n)

circatwenty4.bsky.social•58 days ago

We identified four functional cell types that mediate circadian signaling across the SCN neural network, acting as circadian signal 'generators,' 'broadcasters,' 'bridges,' or 'sinks.' (8/n)

circatwenty4.bsky.social•58 days ago

To identify key hub cells driving SCN network synchrony, we simulated the experimentally inferred SCN maps in 6 mice and tested the impact of ablating various cell types on networks' ability to synchronize. (9/n)

circatwenty4.bsky.social•58 days ago

VIP hubs drive SCN circadian synchrony: We found a topologically unique group of VIP hub neurons that generate and broadcast signals with their extensive and long-range connections. SCN networks did not synchronize on ablating the VIP hubs but not AVP cells. (10/n)

circatwenty4.bsky.social•58 days ago

All signals converged on the dorsal 'sink' cells (including the AVP cells) which were not essential for driving SCN synchrony. We also identified 'bridge' cells in the central SCN that couple information flow across the modules & likely underlie seasonal SCN reorganization (11/n)

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