1/ A new preprint from the @gangfang.bsky.social group highlights challenges in detecting low-abundance modifications with ONT sequencing and proposes a framework to improve reliability.
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Gang Fang
(1st post @BlueSky) Preprint alert🚨a long thread. Cautions in the use of @nanopore sequencing to map DNA modifications: officially reported “accuracy” ≠ reliable mapping in real applications. We performed a critical assessment of nanopore sequencing (across different versions of models) for the 1/n
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