3/ They suggest a framework to calculate FDR per modification and context using the negative control. This helps adjust thresholds, like modification probability (pmod in Dorado), for more reliable detection. - ThreadSky

yishay.bsky.social • 100 days ago

3/ They suggest a framework to calculate FDR per modification and context using the negative control. This helps adjust thresholds, like modification probability (pmod in Dorado), for more reliable detection.